Endocrine Abstracts

A 36-years-old male with mild hypertension was diagnosed with pseudocystic tumor (67 mm) in pancreatic region and liver metastasis in April 2010. One month later, the extirpation of retroperitoneal mass and metastasis was performed in local medical centre. Pathohistological diagnosis was metastatic paraganglioma (Ki67, 3.5%). In June 2010, he was transferred to our Institution, and (131) I-metaiodobenzylguanidine (MIBG) scintigraphy was negative. However ((18) F) fluorodeoxygl...

Introduction: Most patients with neuroendocrine tumors (NETs) present with liver involvement at the time of diagnosis. Trans-catheter arterial chemoembolization (TACE) is accepted treatment of patients with non-resectable hepatic metastases from NETs.Aim: To analyze objective tumor response and clinical outcome in patients with hepatic metastases from NETs who underwent TACE.Methods: Thirty-one patients underwent 140 TACE procedure...

Introduction: The coexistence of adrenal tumors (AT) in patients with neuroendocrine tumors (NETs) has not been extensively studied. The aim of our study was to investigate their prevalence and clinical significance in these patients.Materials and methods: We retrospectively studied 447 patients with NETs of all localizations, treated at our department between 2004 and 2012. Diagnosis was established pathohistologically, classification performed accordin...

Introduction: It has been shown that most women with polycystic ovary syndrome (PCOS) have increased adrenal androgen production, enhanced peripheral metabolism of cortisol and elevated in urinary excretion of its metabolites. Simultaneously, this increased cortisol clearance in PCOS was shown to be followed by a compensatory overdrive of the hypothalamo–pituitary–adrenal (HPA) axis. The aim of this study was to determine HPA axis sensitivity in women woth PCOS.<...

Introduction: Women with polycystic ovary syndrome (PCOS) are characterized with insulin resistance and hyperinsulinaemia. Adiponectin and leptin are adipose tissue-specific products and are correlated with insulin resistance. The aim of the study was to access the relation of adiponectin with anthropometric, metabolic and hormonal parameters in a group of women with PCOS.Methods: We studied 57 non-obese women with PCOS diagnosed using ESHRE/ASRM criteri...

Introduction: Generously supported by IPSEN)-->The coexistence of acromegaly and secondary polycythemia has been described in a few patients. This association was ascribed to GH/IGF1 proliferative effect on bone marrow progenitor cells. In contrast, the presence of myeloproliferative neoplasm (MPN) with documented JAK2 mutation so far has been described in only one acromegalic patient.Methods: We analyzed the p...

Introduction: Hypothalamo-pituitary-adrenal (HPA) axis dysregulation could be a link between polycystic ovary syndrome (PCOS) and cardiometabolic and psychological complications associated with disease.Methods: We analyzed 50 women with PCOS according to ESHRE/ASRM criteria [age 28.66±5.61, body mass index (BMI) 21.94±3.38 kg/m2] and 50 BMI- and age-matched healthy women (control group, CG), (age 28.66±5.63, BMI 22.09±3.70 ...

Interindividual variations in tissue sensitivity to glucocorticoids have been partly attributed to polymorphisms in the glucocorticoid receptor (GR) gene. The aim of this study was to investigate the prevalence of subclinical hypercortisolism (SH) in women with adrenal incidentaloma (AI), and whether BclI variant of the GR gene may contribute to metabolic abnormalities frequently present in these patients. We evaluated 106 women with AI. Anthropometric characteristics...

Germline ARMC5 mutations have been described as the most frequent genetic abnormality found in patients diagnosed with primary bilateral macronodular adrenal hyperplasia (PBMAH). PBMAH is a rare etiology of Cushing’s syndrome. This gene has been proposed to acts as a tumor-suppressor gene. A 36-years old female presented to us with clinical signs of hypercortisolism. ACTH dependent Cushing’s syndrome was confirmed soon after. Pituitary magnetic resonance imaging (MRI...

Introduction: Oligomenorrhoea have negative impact on bone mineral density (BMD). The aim of this study was to analyze BMD in oligomenorrhoeic women with polycystic ovary syndrome (PCOS), and healthy controls with regular menstrual cycles.Methods: We analyzed 29 women with PCOS diagnosed using ESHRE/ASRM criteria (age: 23.6±4.7 years, BMI: 24.9±6.1 kg/m2) and 22 healthy BMI-matched controls (HC) (age 31.6±6.3 years, BMI 24.9&#17...